Comfy Mid-Piety Relic 2.34 GCD | 912 Piety

Safe to use in environments where raises and non-Lily GCD heals are expected. When in doubt, pick one of these sets (Relic or Non-Relic).
Mid-Speed general use set.

Comfy Mid-Piety Non-Relic 2.34 GCD | 912 Piety

Safe to use in environments where raises and non-Lily GCD heals are expected. When in doubt, pick one of these sets (Relic or Non-Relic).
Mid-speed general use set.

Comfy Mid-Piety Relic 2.41 GCD | 852 Piety

Safe to use in environments where raises and non-Lily GCD heals are expected. When in doubt, pick one of these sets.
Low-speed, high ping friendly general-use set.

Comfy Mid-Piety Non-Relic 2.41 GCD | 852 Piety

Safe to use in environments where raises and non-Lily GCD heals are expected. When in doubt, pick one of these sets.
Low-speed, high ping friendly general-use set.

Low Piety Damage Set Relic 2.34 GCD | 682 Piety

Mid-speed, well-suited to more organized reclears, risky in PF and on prog, especially E12S. Similar alternatives using Smoked Chicken and Edenmorn Earing can be found in the gear calculator.

Low Piety Damage Set Non-Relic 2.34 GCD | 682 Piety

Mid-speed, well-suited to more organized reclears, risky in PF and on prog, especially E12S. Similar alternatives using Smoked Chicken and Edenmorn Earing can be found in the gear calculator.

Minimum-Piety Speed Set Relic 2.26 GCD | 340 Piety

High-speed, speedkill-only set. Extremely risky and will run out of mana if any GCD healing or Raises are required, or the fight goes too long. Not for general use.

Minimum-Piety Speed Set Non-Relic 2.26 GCD | 340 Piety

High-speed, speedkill-only set. Extremely risky and will run out of mana if any GCD healing or Raises are required, or the fight goes too long. Not for general use.

Ultimates

TEA Prog set (linked)

2.42 GCD | 1364 Piety
Flexible set able to accommodate a wide range of Piety levels and two different GCDs. Standard setup uses Smoked Chicken for 2.42, you can use Twilight Popoto Salad for 2.41 or Golden Pineapple Juice for some extra Piety. You can put Piety instead of Det on Relic if desired (in any amount you want) and the Piety melds can be stripped out for Det/DH if you feel you want to go lower. (Existing Det melds can be swapped to DH too).

Edenmorn Chest is BiS, use 520 Nier or Augmented Deepshadow otherwise.

TL;DR: Use this as a starting point and adjust to comfort.

UWU / UCOB

The damage checks in UWU and UCOB are trivial with current gear, food and potions. The biggest gear upgrade by far is the 515 or 535 relic, as you can cap multiple substats, but again they are hardly required. I personally recommend 1k+ Piety for prog, with your remaining gear prioritizing Crit > Det/SpS wherever possible. Don’t worry about getting perfect stats, they won’t make a difference for anything but rank one.

The Weapon’s Refrain (UWU)

Gear at item level 470 and above will cap both substats.
Relic stats: 318 Crit, 318 Det, 318 SpS, 213+ Piety

The Unending Coil of Bahamut (UCOB)

Gear at item level 418 and above will cap both substats.
Relic stats: 280 Crit/Det/SpS/Piety