6.4 2.50 GCD set
The generally recommended set for 6.4 content.
6.4 2.45 GCD set
This set is not recommended unless you have a specific use case in mind — it performs at best around the same as the 2.50 set, but is more difficult to use.
Dragonsong's Reprise (Ultimate) 2.50 GCD set
The DSR weapon and the Asphodelus weapon are both viable (but slightly worse) replacements for the Manderville weapon, melded with DH for the 2.50 set, and SkS for the 2.45 set. The 6.55 relic can replace the older relic with no changes to the set.
Dragonsong's Reprise (Ultimate) 2.45 GCD set
The DSR weapon and the Asphodelus weapon are both viable (but slightly worse) replacements for the Manderville weapon, melded with DH for the 2.50 set, and SkS for the 2.45 set. The 6.55 relic can replace the older relic with no changes to the set.
6.55 The Omega Protocol (Ultimate) 2.50 GCD set
The TOP weapon and the Abyssos weapons are both viable (but slightly worse) replacements for the Manderville weapon, melded with DH for the 2.50 set, and SkS for the 2.45 set. The 6.55 relic can replace the older relic with no changes to the set.
6.55 The Omega Protocol (Ultimate) 2.45 GCD set
The TOP weapon and the Abyssos weapons are both viable (but slightly worse) replacements for the Manderville weapon, melded with DH for the 2.50 set, and SkS for the 2.45 set. The 6.55 relic can replace the older relic with no changes to the set.
6.55 2.50 GCD with Relic
6.55 2.45 GCD with Relic